![]() ![]() It is associated both with excessive loading and mechanical disadvantage of inspiratory muscles and with restriction of normal tidal volume expansion during exercise ( 2). Dynamic hyperinflation (DH), which occurs independently or in addition to static hyperinflation, refers to the increase of lung volumes above their resting value that occurs with increases in respiratory rate due to expiratory flow limitation. Static hyperinflation is due to the reduced elastic recoil of the lung. ![]() One of the consequences of airflow limitation and permanent parenchymal destruction is lung hyperinflation ( 1, 2). Homogeneous emphysema is associated with more DH during maximum exercise in COPD patients.Įxpiratory flow limitation is the pathophysiologic hallmark of Chronic Obstructive Pulmonary Disease (COPD). Upper lobe predominance of emphysema correlated positively with peak oxygen pulse, peak oxygen uptake and peak respiratory rate, and negatively with ΔIC%. ΔIC% was significantly higher in homogeneous emphysema (39.8% ± 9.8% vs.31.2% ± 13%, p = 0.031), while no other CPET parameter differed between the groups. The groups were matched for all baseline variables. Emphysema quantification was conducted at 3 predefined levels using the syngo PULMO-CT (Siemens AG) a difference >25% between best and worse slice was defined as heterogeneous emphysema.įifty patients with heterogeneous (62.7% male 60.9 ± 7.5 years old FEV 1% = 32.4 ± 11.4) and 14 with homogeneous emphysema (61.5% male 62.5 ± 5.9 years old FEV 1% = 28.1 ± 10.3) fulfilled the enrolment criteria. ΔIC was calculated by subtracting the end-exercise inspiratory capacity (eIC) from resting IC (rIC) and expressed as a percentage of rIC (ΔIC %). #Vmware workstation pro license by instillation or by user full#This was a retrospective analysis of prospectively collected data among severe COPD patients who underwent thoracic high-resolution computed tomography, full lung function measurements and maximal CPET with inspiratory manouvers as assessment for a lung volume reduction procedure. The aim of this study was to investigate the impact of emphysema distribution on DH during a maximal cardiopulmonary exercise test (CPET) in patients with severe COPD. Dynamic hyperinflation (DH) is a pathophysiologic hallmark of Chronic Obstructive Pulmonary Disease (COPD). ![]()
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